EFFICACY OF ORAL AND INTRAMUSCULAR VITAMIB B12 IN EARLY RESPONSE AND PREFERENCES OF PATIENTS
Abstract
BACKGROUND: Deficiency of vitamin B12 can be managed by oral substitution or intramuscular injection of vitamin B12. When different administration routes are present, the preference of patients should also be considered while treatment selection.
OBJECTIVE: The main objective of our study was to assess the preferences of patients towards intramuscular injection or oral treatment of vitamin B12 supplementation, and to confirm the efficacy of both treatment options in patients.
METHODOLOGY: This was a prospective clinical trial, conducted at tertiary care hospital for a period of one year (June 2020 to May 2021). A total of 42 patients were selected for study. Patients were randomly and equally allocated to oral (21 patients) or intramuscular treatment groups (21 patients). In Group A, patients were given oral tablets of 1000μg cyanocobalamin, while in Group B, 1000μg hydroxocobalamin injections were given to patients. Samples of whole blood were extracted before starting of treatment, followed by 1, 2 and 4 weeks of treatment, and were analyzed for serum vitamin B12 levels. Before and after treatment, the patients were asked to fill questionnaire regarding preference of treatment options. SPSS 24.0. was used for analysis. A p-value of <0.05 was considered as statistically significan
